The way I prefer to use RTSS is to only whitelist specific applications. I have Application Detection Level set as "None" on the global profile. If I search for "RTSS" in Process Explorer, I can see RTSS hooked into all sorts of processes that have not been whitelisted. Even applications which I have specifically blacklisted by creating a profile with "EnableHooking=0" are having RTSSHooks.dll or RTSSHooks64.dll injected into them. This causes many problems, including updating RTSS, as it hooks into system processes and does not unload when RTSS is closed. I then have to log out or even restart the PC before I can uninstall/update RTSS. I believe it could also be related to why RTSS is breaking the Windows 10 (1803) Game Bar process (it doesn't just block the overlay; it crashes GameBar.exe). This seems to be affecting significantly more applications now in 7.2.0 Beta 1.