Unwinder, I have found that changes made to the Global Settings (I don't know about individual game profiles) via the NV control panel not only change the settings in the registry but also their respective settings for the "Base Profile" in "C:\ProgramData\NVIDIA\NvApps.xml". This file is apparently used by the NV control panel to display what it thinks are the current settings in the registry. When changes are made with RT to a particular setting such as the Intellisample Mode, the registry is properly updated but NvApps.xml is not. This causes the NV control panel and RT to be 'out of sync' with one another. Is it possible in a future RT update to change this so that the NV control panel will recognize the correct settings from NvApps.xml? Running Vista Ultimate 64-bit and NV drivers 169.25. I don't know if this issue is seen with other drivers or other versions of Windows.