Have this Enabled on my ASUS Crosshair VII HERO X570. Have the 6800 XT but not the 5000 series yet. Still can't find a 5900x that isn't on ebay or another reseller marked up double by scalpers. I haven't noticed anything too extreme, but I haven't a method to test either. I do see some loading times improved but not sure if its because of Resizable BAR and Above 4G encoding or not. Either way both are enabled and running, no glitches, no mess, no downwards performance issues.