I have the follow: Samsung SSD 860 EVO 1TB 2Tb WD Black 4Tb Seagate Ironwolf 4Tb WD External Drive 4Tb Seagate External Drive I narrowed down what was causing my issue with the underlined Seagate External Drive. Every single time I enable Rapid Mode for my 860 EVO, the 4Tb Seagate External Drive will not open and I get this error code: If I disable Rapid Mode and restart, problem solved. Tested for 1 straight month without using Rapid Mode if the HDD shows any errors or any signs of issues, and nothing. Enable Rapid Mode again on my Samsung SSD (which should have nothing to do with my other drives), and the same issue is back now. The other way to temporarily solve this problem is have Rapid Mode on, but after every boot, unplug and plug back in the Samsung External Drive to solve this issue. I hope someone knows of a solution, or why this problem happens with Rapid Mode enabled.