Enhancing is always different than Forcing. Pretty much any game DX10+ that has MSAA in game can be enhanced (Though often to mixed results that require additional downsampling) In Vulkan the calls in the driver to enhance probably don't exist because half the point of Vulkan is to give the application lower level control right? I haven't seen any examples of a program with a Vulkan backend that also offers MSAA support to attempt to enhance it to SGSSAA. Though I don't think it would work anyway. That would make sense that it can't interfere. Wrapping DX9 would of course change things. Because the driver is being fed whatever other API instead by the wrapper. It's intermediating between the two. I played a few hours of Killing Floor with forced SGSSAA and sharpening and after some time after boot up I never noticed the screen shaking again. (I still ended up going back as I was used to how the game looked anyway. If you want less blurry SGSSAA in KF you just have to disable Bloom) I haven't tried other games though.