You can't enhance or force TrSSAA with 2x2 OGSSAA, since this SSAA mode doesn't contain any MSAA samples for TrSSAA to utilize. MSAA and TrSSAA/SGSSAA must always be used together To do what you are asking, you would need something like 16xS (2x2 OGSSAA + 4xMSAA) + 4xTrSSAA, or alternatively 8xSQ (2x2 OGSSAA + 2xMSAA) + 2xTrSSAA. But this is quite demanding in most modern titles, and would use too much VRAM in Skyrim with high res texture mods. Instead I recommend running at 1920x1080 or 1920x1200 and forcing 4xMSAA+4xSGSSAA or 8xQ MSAA+8xSGSSAA with "0x000002C1" (MSAA, FXAA and DoF should be disabled ingame): http://www.forum-3dcenter.org/vbulletin/showpost.php?p=10184469 If this is too demanding or uses too much VRAM for your system, then enhancing the ingame MSAA setting with SGSSAA also gives a nice result. But of course not as perfect as with forced SGSSAA with "2C1"