Nvidia 355.60 WHQL Windows 10 drivers out now

Do we need Display/GPU Scaling enabled with DSR ? because some games at least on my laptop windows 8.1 x64 drivers 349.88 I think. if I don't enable the GPU Scaling when choosing 2560x1440p it works but I can't click with the mouse on the menus , it's like the mouse is not on the screen and somewhere else because of the downsampling. when enabling the GPU Scaling then the mouse is able to select and click on the menus. I can't explain it other way.