Well running it 24/7 is just the best thing to do, when you have High CPU voltage. But turning the system ON and OFF is the thing that will kill the CPU, because the system voltage spikes can be so high in a split second, that it can burn the CPU internally. Something like this happen very recently to a YouTuber. I bet MSI didn't test the system's by turning it ON and OFF for 100 times to see if the CPU would survive. And a very good PSU can save your CPU to, that actually has voltage peak protections.