I ordered a couple cheap ($16/$26) vertical mice that show up this week. My wrist, hand and elbow for my mouse hand seem to be in more pain as I age (46). These new mice look pretty bizarre but are supposed to alleviate the pain. If I like it, I'll buy one of the nicer ones (Logitech MX vertical) but there really isn't that great of a selection. I never liked ergonomic keyboards so I dunno about these odd mice, but I have to try something. I usually get a new mouse about every other year. I've am using a Logitech G602 and it's a great wireless mouse with fantastic battery life. Too many thumb buttons and my pinky finger drags and tires easily though.