Fixing to tackle the Mass Effect trilogy, or at least the ones on Steam. Found a number of threads pointing out that SGSSAA can be used if one manually changes the antialiasing compatibility bit to 0x080000C1, from its profile default of 0x00000045. Anyway, that's what I did: Antialiasing compatibilty: 0x080000C1 Antialiasing - Mode: Override any application setting Antialiasing - Setting: 2x [2x Multisampling] Antialiasing - Transparency Multisampling: Disabled Antialiasing - Transparency Supersampling: 2x Sparse Grid Supersampling With these settings, what I noticed right away was that glows and depth of field blurs would give a vertical line artifact: (I cannot post images yet, but it's on imgur as m7dRQkV.jpg.) I eventually discovered that changing the antialiasing compatibility bit back to 0x00000045 caused the artifact to disappear. What I don't know at this time is whether this happened because I missed something obvious or because it's just a drawback of using that particular compatibility setting -- one that has evidently gone essentially unnoticed.