Parkinsons is caused by a loss of dopamine production cells in the substantia nigra, marijuana improves the receptiveness of the dopamine receptors in the brain allowing them to function more effectively on less available dopamine. Dopamine is inhibited and surpressed by Cortisol, so while the man was struggling against his twitching body, he wasn't giving the brain the dopamine to do its job.
As I understand it, THC stimulates endocannabinoid receptors and to some extent dopamine receptors. Cannabis would tackle some of this by putting a dopamine equivalent in where some is inherently missing. As far as I know it doesn't affect the receptor sensitivity. Its use as medicine is difficult as overstimulation of cannabinoid receptors also effects receptors downstream, so its overall pharmacokinetic profile is difficult to predict entirely as varies a lot from person to person. Problems with dosing includes maintaining therapeutic thresholds in context of emerging tolerances, which makes it difficult to use safely in Parkinson's. Other reasons why not a recommended treatment in Parkinson's is the secondary effects which Parkinson's sufferers are usually more susceptible to - behavioral changes, hallucinations, emotional changes, sleepiness etc. As for use in epilepsy, some (very) rare forms of epilepsy are responsive to it. Many others however it increases seizure frequency because its use varies an individuals neurochemistry/neuroendocrine levels, which can trigger seizures in people that naturally have low thresholds for having them.
I'm going to try and get a dab rig and THCA diamonds. THCA is the precursor to Delta 9. When it's heated it turns into Delta 9. Real marijuana is mostly THCA. *EDIT* I smoked THCA flower for a while and liked it. Didn't want to smoke any other flower. It's pretty close to the real thing. The only downside was finding flower that also had high amounts of C.B.D in it. You're pretty much getting straight delta 9 so why not any C.B.D?
Whatever you guys do you should always get you cannabis products from places and websites that sell it as medicinal and wellness products. 9 times out of ten they make and sell their own shet so they know more about it and actually know what the frack they're doing. Not only that they probably sell the better formulated products.
THCA vapes are the real deal if you want to vape psychoactive cannabis in states where D9 is still illegal.
It's the first time i've hears about alt-noids, all i care about is weed and the products made from it, i like c.b.d. too but it's best when mixed with the real stuff. I care not for products made in a lab you really gotta be careful with them, nothing will ever get close to the real deal.
I already know that's true. Looking back I hated that spice crap that was going around during the late-00's in my early teens. I was thinking about trying shrooms if or once that's ever legal, I absolutely hated that psychedelic "synthetic weed" garbage though. It made everything feel like was on the inside of a cartoon,
Careful with shrooms, make sure you do them in a comfortable environment with close friends. It's easy to have a bad trip depending on their potency.
This hemp derived s**t needs C.B.D and the other cannabinoids. . There's no way I'd make a post like this while stoned out of my mind just vaping or smoking any THC alone. *EDIT* What I mean by smoking any THC alone I mean when they use the industrial hemp that has very little CBDA in it or anything like CBG. Just fracking 23% THC and 7% 50 other noids.
Micro-dosing shrooms is the way to go. I tried spice way back then too, didn't get much from it guess i didn't smoke enough, just gave me a sore head really.
Who's House? Spoiler Run's House! Hey, God loves you guys and gals so much, don't be tough on yourselves, hard times we're going through, be good people we must! as yoda would say.❤️✌️
I ordered 98 RAW king size preroll cones that cost $5 on Amazon. I'm going to get the six shooter preroll packer also. This should save me $$. About vaping, I was vaping THCA and bought a THCA preroll one day and the preroll was way stronger then 20 minutes of vaping.
