I tried countless different ways of getting folding@home to work with my 5970 & 9800gtx+ at the same time and I finally got it to work!! I'm running a Sapphire 5970 as my primary and a EVGA 9800gtx+ for physx. I'm running CCC 10.8 and 258.96 drivers for my Nvidia with the Physx 1.44 mod. This is how I did it: 1. Install all the drivers, including physx mods. After you get both cards working properly- Reboot. 2. Install the f@h gpu 2 console client and run it, it should by default use the nvidia card. (I used the -gpu 0 flag, I'm not sure if that makes a difference, I haven't tried this without it). Reboot. 3.Go to the device manager and disable the Nvidia card then reboot. 3. Install the GPU 3 system tray client. It should use the ATI card by default. 4. With the GPU 3 running on the ATI, go back to the device manager and enable the Nvidia card. 5. Run the gpu console client Thats it!! I've checked gpu-z and it shows a 99% load on both cards. Make sure you remove the gpu 3 system tray from the startup folder. If you reboot with the nvidia still enabled and the GPU 3 client starts it will wipe out the ATI settings and you have to start from scratch. When you're going to fold with both just disable the Nvidia, start the GPU 3, re-enable the nvidia and start the GPU 2.