I have a 780 ti SLI connected to a triple monitor setup ( 3x dell u3011 @ 7680x1600). In some games such as max payne 3, crysis 1 and euro truck simulator 2, setting the game to the max res will cause the audio to periodically crackle and cut out entirely from either the left, the right or any of the speakers for that matter. However, when i set the resolution down to 2560x1600 which only uses one screen, the audio issues disappear entirely. I'm not sure what the issue is. could it be that a somewhat lower frame rate from using all three screens can negatively affect the audio quality in some way?