Edit: After further testings, it seems that MSI mode is not the reason why my issue went away, will update my post #4 with new findings with further testing as it's a wip right now. Hey guys, Long time reader here but registered today to let you guys know about this fix (since ya know, couple of million of people might be interested to get those drivers working for optimal experience for Cyberpunk 2077 ) My main setup: MSI Z270 Gaming M5 6700k 1080Ti MSI Gaming X W10x64 - 20H2 (Build 19042.685) And for the purpose of this post, my monitor: Dell S3220DGF hooked through DP @ 164Hz - Gsync compatible always enabled + Vsync On in Nvidia cp * I always install minimal drivers as I remove all the clutter and only leave the Display.Driver, NVI2 and Physx folder only, so it might (or not) have an impact. I Also constantly use MSI afterburner (currently 4.6.2) and RTSS that comes with the install. So, right on install of those 460.79 (I also always use DDU in safe mode prior to install), I got right away that screen flickering issue (which I never had before) and it was bad, obvious flickering that could not go unnoticed, even idle on desktop... Nevertheless, I did my usual extra step (which I do right after each fresh install of Nvidia drivers because Nvidia has this disabled by default), just in case it might change something... and it totally did! The fix: I just put my gpu in MSI mode (Message Signaled-based Interrupts), rebooted, never had one flicker since! For those who dont know about MSI mode, just read @mbk1969 's excellent post and download his tool (link for it is in his 1st post) here: https://forums.guru3d.com/threads/w...ge-signaled-based-interrupts-msi-tool.378044/ For those who don't want to edit their registry manually, with his great great tool that he provided us with, literally a couple of mouse clicks, reboot and you're done! YMMV because not 100% of configs play nice with MSI mode, but those problems should be limited to very old configs / gpu's. Any "relatively new" (roughly 5 years or less) hardware shouldn't have any problems with MSI mode for your GPU. Hope this helps at least a few of you out there and if it does, spread the word!