Good morning Everyone... Before I begin, I already posted this situation on Asus forums last week, I have not got a reply yet. I just recently hooked up another Folding@home/Boinc system, the motherboard in question: Asus x99 Rampage V Extreme(With the most/up to date bios firmware). Before going any further, two things, I am using a 40 lane cpu and I am not using an M.2. drive. I have 4 Gpu's installed, and within the bios, under Gpu post, 3 gpu's are being detected but the 4th one is not being detected and its @ x4 speeds. Although everything is working pretty good in windows, I checked under Gpu-z, Its running @ x16/x8/x8/x4. In the users manual, it stated that if your using a 40 lane cpu(which I am) and not using a M.2. Drive(which I am not), the board can run @ x16/x8/x/8x8 configuration. The only thing I can change within the bios is the actual gen speeds, not the actual slot speed width(Bifurcation/don't really know if the board supports this feature). On the top right of the motherboard, there is a thing called: Pci-e Lane Switcher, the only one that's basically lit after going into bios, Pci-e slots: 1,2, & 3 are lit, the 4th one, no, I tried toggling the 4th pci-e lane switch, same as before. The 4th slot that's having this problem: PCIe 3.0 X8_4 slot. I also notice that some people have actually modded their bios to able to splice up their pci-e slot speeds. Take a look at this link: https://www.win-raid.com/t3323f16-Guide-How-to-Bifurcate-a-PCI-E-slot.html#msg45202 I also used a program called: AMIBCP and looked for the: IIO PCIe port, I only see 3 ports, 4th one is not there, why is the 4th one is missing? Under IIO, there is 4 within the drop list, II0,II1,II2, And II3, If you look into any of them, Look for: (IIO PCIe Ports), there is only port 1,2 and 3 within each IIO. I am still very new into Bios Modding, Hopefully it is not needed for what I need. Just heads up, Folding@Home ppd, despite the 4th slot running @ x4(Gen 3), I am not losing any ppd at all, its the same amount as the X16 speeds. If anyone is interested in looking at the user's manual, here's the link: https://dlcdnets.asus.com/pub/ASUS/...1/E9550_RAMPAGE_V_EXTREME_UG_for_web_only.pdf EDIT: Just heads up to everyone, I personally tried using just 1 Gpu on the last Slot, and under bios settings, Gpu Post, it still says no vga being detected even though I am still getting video signal on that slot.