Thanks for the info. For me Disabling crossfire in gameprofiles has always put the second card in sleep mode. That has stopped working with crimson 16.1. I have now reverted to Catalyst 15.11.1 and eveything is back to normal. The second video card is always sleeps correctly in desktop mode. Disabling crossifre for games works and most importantly, all my older games work in full screen with the 2 other U2515H screens showing my extended desktop. So those games not working in full screen only happens with crimson drivers and i have tested it with Crimson 15.12. So this bug has been carried since. I am thinking of making a thread here at Guru3d to discuss it. I have searched everywhere and at AMD community support there are a couple of post about this issue but no discussions and nothing mentioning this problem here. Now I am not sure but I think performance in GTA5, Showdow of Mordor, Deserts of Kharak was a tab bit smoother with Crimson drivers. But I am currently playing my older games so I am going to stick with 15.11.1 until AMD fixes this issue with the extended desktop.