Create a game profile and set the CrossFire setting to "AFR compatible". This should enable CrossFire for games without an associated application profile. Ever since they removed the checkbox, Crossfire didn't work for ESO and Anno 2205. It really sucked that they removed the checkbox, but the AFR compatible seems to do the exact same thing as the checkbox. However, you have create a profile for every game, to enable it. The checkbox was much better.